Key Affiliations
1. Full Professor, Charité – Universitätsmedizin Berlin, Germany
2. Head, Molecular Epidemiology Unit, Berlin Institute of Health
3. Professor, Intelligent Medicine Institute, Fudan University
Research Focus
1. Molecular Epidemiology
2. Environmental Epigenetics
3. AI-Driven Respiratory Medicine
Groundbreaking Contributions
1. COVID-19 Pathomechanisms
1) Pioneered nasal swab single-cell sequencing to decode SARS-CoV-2 infection (Nature Biotechnology2020/2021)
2) Identified therapeutic targets for severe COVID-19 (leading to Bayer-sponsored Phase II trial)
2. Early-Life Disease Programming
1) Mapped genome-wide methylation signatures in childhood asthma (Allergy 2023)
2) Revealed epigenetic regulation of metabolic disorders by environmental pollutants (Nature Communications 2020)
3. AI-Clinical Translation
1) Lead €13M EU project: Real-world machine learning models for COPD/asthma management
2) Developed multi-omics frameworks for personalized disease risk prediction
Academic Impact
1. 300+ publications, >17,000 citations, h-index 68
2. Principal Investigator for key German federal grants ( >€3.7M)
Research Agenda at Fudan
1. Translational Programs
National Natural Science Foundation project: "COPD Exacerbation-to-Lung Cancer Transition" with Zhongshan Hospital
2. Intelligent Medicine Platforms
1) Building single-cell multi-omics databases for respiratory diseases
2) Developing AI-enabled clinical decision support systems
Global Engagement
1. Conference Chair: Systems Biology of Human Disease(2018–present)
2. Co-founder: Sino-German Joint Laboratory for Intelligent Medicine (with Prof. Roland Eils)
