Researcher, doctoral supervisor, received a bachelor's degree from the School of Life Sciences of Fudan University in 2003, and went to Johns Hopkins University School of Medicine in the United States to study for a doctorate in the same year. In 2009, he received a master's degree in biostatistics from the Johns Hopkins University School of Public Health and a double degree in molecular biology and genetics from the Johns Hopkins University School of Medicine. From 2009 to 2014, he did postdoctoral research at the Epigenetic Center of Johns Hopkins University in the United States. In 2014, he was employed as a researcher in the Department of Biochemistry and Molecular Biology, School of Basic Medicine, Fudan University.
Liu Yun's laboratory uses the method of epigenetics to study the causes and biochemical mechanisms of DNA methylation in drug and alcohol addiction, as well as complex human diseases (such as obesity, etc.). Academic achievements have been published in the world's first-class academic research journals such as Immunity, Nature Genetics, Nature Biotechnology, and The American Journal of Human Genetics. In the past five years, his papers have been cited more than 600 times, and his academic achievements have been widely reported by many major media including the New York Times.
research direction
representative paper
Lu C, Ward A, Bettridge J, Liu Y, Desiderio S (2015). An Autoregulatory Mechanism Imposes Allosteric Control on the V(D)J Recombinase by Histone H3 Methylation. Cell Rep, 10:1-10.
Liu Y, Li X, Aryee MJ, Ekstrom TJ, Padyukov L, Klareskog L, Vandiver A, Moore AZ, Tanaka T, Ferrucci L, Fallin MD, Feinberg AP(2014). GeMes: Clusters of DNA methylation under genetic control can inform Genetic and epigenetic analysis of disease. Am J Hum Genet, 94:485-495.
Liu Y, Aryee MJ, Padyukov L, Fallin MD, Hesselberg E, Runarsson A, Reinius L, Acevedo N, Taub M, Ronninger M, Shchetynsky K, Scheynius A, Kere J, AlfredssonL, Klareskog L, Ekstrom TJ, Feinberg AP( 2013). Epigenome-wide association data implicate DNA methylation as an intermediary of generic risk in Rheumatoid Arthritis. Nat Biotechnol, 31:142-147.
Hansen KD, Timp W, Bravo HC, Sabunciyan S, Langmead B, McDonald OG, Wen B, Wu H, Liu Y, Diep D, Briem E, Zhang K, Irizarry RA, Feinberg AP(2011).Increased Methylation Variation in Epigenetic Domains Across Cancer Types. Nat Genetics, 43:768-775.
Liu Y, Subrahmanyam R, Chakraborty T, Sen R, Desiderio S(2007). A Plant Homeodomain in RAG-2 that Binds Hypermethylated Lysine 4 of Histone H3 is Necessary For Efficient Antigen-Receptor-Gene Rearrangement. Immunity,27:561- 571.
