Personal profile
1. Name: Yu Hongxiu, researcher at Fudan University Biomedical Research Institute, doctoral supervisor, Shanghai Pujiang talent, distinguished professor of Shanghai Minhang Hospital, deputy director of the Department of Medical Systems Biology, Fudan University School of Basic Medicine
2. Address: Room 501, Mingdao Building, No. 131, Dong'an Road, Xuhui District, Shanghai
3. Email: hongxiuyu@fudan.edu.cn
Educational experience (in reverse chronological order from undergraduate)
2002/09-2005/06, Fudan University, School of Life Sciences, State Key Laboratory of Genetic Engineering, PhD;
1999/09-2002/06, University of Science and Technology of China, School of Life Sciences, Cell and Molecular Biology, Master;
1993/09-1997/06, Nankai University, School of Life Sciences, Department of Microbiology, Bachelor.
Main research work experience (in reverse chronological order)
2012/03-present, Fudan University, Biomedical Research Institute, associate researcher, researcher, mainly research protein post-translational modification such as acetylation modification, succinylation modification on the regulation of protein function and the role in the process of tumor development; sugar , the regulation of lipid and amino acid metabolism on the function of tumor cells and immune cells;
2010/12-2012/10, University of California, Los Angeles, Department of Physiology, National Heart Lung Blood Institute, NHLBI Proteomics Center, Senior Visiting Scholar, mainly researching mitochondrial proteins Effects of post-translational modifications on cardiac physiological and pathological functions;
Main research direction
Combining biological mass spectrometry, cell molecular biology techniques and animal models to study the functions and mechanisms of metabolic enzymes and metabolites in the process of inflammation-cancer transformation.
Representative Papers
Cuiping Zhang#, Ke Wang#, Zuojian Hu#, Lujie Yang, Bin Wei, Shan Li, Xue Qin, Pengyuan Yang*, Hongxiu Yu*. SIRT5 is important for bacterial infection by regulating insulin secretion and glucose homeostasis. Protein & cell, 2020, accepted. (IF=10.16)
Cuiping Zhang#, Zuojian Hu#, Ke Wang#, Lujie Yang, Yue Li, Hartmut Schlüter, Pengyuan Yang*, Jiaxu Hong*, Hongxiu Yu* . Lipidomic Profiling of Virus Infection Identifies Mediators that Resolve Herpes Simplex Virus-Induced Corneal Inflammatory Lesions .Analyst,2020, DOI: 10.1039/D0AN00263A. (IF=4.1)
Cuiping Zhang, Ke Wang, Lujie Yang, Ronghua Liu, Yiwei Chu, Xue Qin, Peng yuan Yang and Hongxiu Yu* . Lipid metabolism in inflammation-related diseases. Analyst, 2018, 143, 4526. (IF=4.1)
Fang Wang, Ke Wang, Wei Xu, Shimin Zhao, Dan Ye, Yi Wang, Ying Xu, Lisha Zhou, Yiwei Chu, Cuiping Zhang, Xue Qin, Pengyuan Yang,* and Hongxiu Yu*. SIRT5 Desuccinylates and Activates Pyruvate Kinase M2 to Block Macrophage IL-1b Production and to Prevent DSS-Induced Colitis in Mice. Cell Reports. 2017, 19, 2331–2344. (IF=8.28)
Lisha Zhou#, Fang Wang#, Renqiang Sun, Xiufei Chen, Mengli Zhang, Qi Xu, Yi Wang, Shiwen Wang, Yue Xiong, Kun-Liang Guan, Pengyuan Yang, Hongxiu Yu* , Dan Ye*. SIRT5 promotes IDH2 desuccinylation and G6PD deglutarylation to enhance cellular antioxidant defense. EMBO reports, 2016,17(6):811-822. (IF=8.57)
Major fund support in the past five years (the total amount exceeds 5 million)
National Key R&D Program, 2021YFC2701800, Establishment of accurate etiological diagnosis strategy for children with severe infection, 2022/01-2024/12, ongoing research, participation;
General project of the National Natural Science Foundation of China, 82073077, research on the mechanism of branched-chain amino acids promoting Treg cell differentiation in the occurrence and development of colon cancer by activating the mTORC1 signaling pathway, ongoing research, host;
National Key Research and Development Program, 2018YFA0800302, Metabolite Regulation of Methylation Profile Establishment in Early Embryo Development, ongoing research, participation;
General project of the National Natural Science Foundation of China, 81872258, the role of SIRT7 desuccinylated SHMT2 in T cell amino acid metabolism and anti-tumor immunity, ongoing research, host;
General project of the National Natural Science Foundation of China, 81672746, the role and molecular mechanism of SIRT5 regulating macrophage metabolism in the malignant transformation of colitis-colon cancer, ongoing research, host;
General project of the National Natural Science Foundation of China, 81472566, research on the mechanism of succinylation of M2-type pyruvate kinase PKM2 regulating the energy metabolism and proliferation of liver cancer cells, completed, presided over;
